Extravascular FIX and coagulation

Extravascular FIX and coagulation

This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 days post-infusion, FIXWT (BeneFIX) is able to control bleeding as well as the same dosage of Alprolix in hemophilia B mice, tested using the saphenous vein bleeding model (Alprolix is a ch...

Malignant Tumor and Extravascular Coagulation

悪性腫瘍患者に血液凝固障害が高頻度に合併 することは従来 よりよく知 られている.そ の成 因については,凝 固・線溶系はもちろんのこと, 単球,血 小板,血 管内皮細胞が複雑 に腫瘍細胞 とかかわ りをもち,さ らにそれ らは悪性腫瘍め 増殖 ・転移にも影響 を与えていることが明 らか になってきたが,い まだ不明の点 も多い.臨 床 的には悪性腫瘍患者は血小板寿命短縮のために 出血傾向を来た したり,肺,膵,子 宮,卵 巣癌 患者の10~50%に 深部静脈血栓が合併す るこ とが知 られている1)2).組織学的 には腫瘍細胞 のまわ りに血小板,フ ィブ リンの沈着が証明さ れている3)~6).また腫瘍細胞 は,局 所だけでな く全身の凝固系にも影響 を及ぼし,結 果 として DICや 血栓への進展 に結びつ く.こ の ように 腫瘍細胞 と凝固系の相互作用は非常に複雑であ る....

Regulation of extravascular coagulation by microvascular permeability.

Extravascular coagulation is a prominent feature of such important pathological processes as cellular immunity and neoplasia and has been thought to result from procoagulants associated with the inflammatory or tumor cells peculiar to these entities. It was found that increased microvascular permeability alone is sufficient to induce equivalent extravascular coagulation in several normal tissue...

Factor IX in intravascular and extravascular blood coagulation.

Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase.

We recently characterized a heparin-deficient mouse strain generated by targeting the gene for N-deacetylase/N-sulfotransferase-2 (NDST-2). The NDST-2-/- mice show severe defects in their organization of mast cell (MC) secretory granules, with an almost total absence of the various heparin-binding MC proteases. In the present report we have studied the consequences of heparin/MC protease defici...